Her filmmaking career has become noted for winning awards and working with high-profile organizations including Univision, AARP, the Catholic Church, and the World Bank.
[3] Through her father's lineage, Cecilia is the great-granddaughter of the geologist and scholar Ignacy Domeyko who after participating in the 1830 Polish Uprising against Czarist Russia, was exiled in Paris, where he was subsequently hired by the government of Chile to teach mining to Chilean students.
Due to her father's career, Domeyko's upbringing would include frequent stretches of living abroad in Chilean embassies in Australia, the Dominican Republic, the United States, and Canada.
In 1998, Domeyko's film Magic Wool premiered at the Kennedy Center in Washington, D.C. as part of Chile's National Day celebration.
[14] The film, which Domeyko directed, produced, and wrote about a group of peasant women in Chile who embroider tapestries about their lives and dreams, had also aired on the Discovery Channel For Latin America.
In an interview with Juventud Rebelde, Domeyko states that her inspiration for the film came from reading the book En el Tiempo de las Mariposas by Julia Alvarez.
Key scenes of the documentary were filmed with actors in Cuba, which is noteworthy as this took place at a time when it was difficult for filmmakers and media members to get access to the island under the Castro regime.
[9] The film premiered at the Embassy of Canada in Washington, D.C. and was also included in the VII Festival de Cine Latino to more than 30,000 spectators where it was one of 42 finalists chosen from over 200 intentional entries.
[21][23] Alongside her journalistic writing, Domeyko received early recognition as a published author for her book Lily, written in conjunction with Venezuelan film director, Abraham Pulido [es], which won the City of Caracas ANAC 1982 Script Award and was later adopted into a film by Pulido, winning the 1984 Venezuelan Best Picture award.
[24] In 2017 Domeyko released the novel Sacrificio en la Frontera, a love story taking place on both sides of the US-Mexican border and that deals with the issue child trafficking.
[27] On November 14, 2019, the Chilean Embassy in Washington D.C. held a promotional event for Sacrificio en la Frontera that included a talk, interview, and question and answer session with Domeyko, as well as selected readings with passages interpreted by actors Dayan Aldana, Melissa Strova-Valencia, Yecid Benavides, and Ricardo Sanchez.
Domeyko's broadcast journalism career was centered in covering Washington D.C. news, including the White House, Capitol Hill, and the US Department of State.
[21] Her other on-camera roles included breaking coverage and production credits for America Today, an international program broadcast to 44 countries, and the United States Information Agency where she hosted specials on major events such as the Women's Conference in Beijing.
[24][21] Domeyko was also a bilingual live anchor for Eternal World Television Network covering Pope John Paul II 1998 visit to Cuba, coverage of which garnered a worldwide audience of 350 million viewers.
[8] Notable examples include the production and release of the films Cuba Mia: Portrait of an All-Woman Orchestra, Code Name: Butterflies, and Havana City of Soul: Walking the Streets of History.
[9] Domeyko won the 2008 National Association of Telecommunications Officers and Advisors Award (NATOA) for concept design, directing, writing, and producing of "Celebremos Lo Latino," a Spanish magazine show for Channel 25 of Baltimore.