[3][2] After her formation, she was assigned in various roles and responsibilities as Religion and Values Education teacher, School Treasurer, Principal and President of the College.

[4] In 2013 and 2014, Espenilla attended the sessions of the Commission on the Status of Women (CSW57 and CSW58) at the United Nations Headquarters in New York City representing Dominican Sisters International (DSI) Coordinator for Asia-Pacific.

[2] In 2016, she was accepted as one of the 8 Fellows of the Center for Women of Faith and Leadership (CWFL) at the Institute for Global Engagement (IGE) in Washington, D.C..[5] She was invited as one of the main speakers to the 26th session of the Commission on Crime Prevention and Criminal Justice (CCPCJ) at the United Nations in Vienna, where she presented the topic "Human Trafficking: How Demand Creates Supply".

[6][5] Also in 2016, she was elected as the main animator of Talitha Kumi Philippines, an organization of consecrated religious that aims to counter human trafficking and abuses.

[3][4] During her tenure, she advocated efforts and focus on ending human trafficking, encouraging religious communities around the world in getting involved in justice initiatives on an international and national level.