Cecilia was born on July 16, 1693, in Calumpit, Bulacan to half-Kapampangan parents.

Together with her older sister Dionisia, they settled down near the shrine of the Our Lady of Mount Carmel in Manila.

Their devout life attracted the attention of the Recollects who were taking care of the shrine and by July 1725, the sisters received the habit of tertiaries and were gathered in a nunnery.

After years, they headed a congregation called Augustinian Recollect Sisters.

On September 10, 1999, the causes for the beatification of the Talangpaz sisters were opened, bestowed with Nulla Osta and thereby giving them the title Servants of God.