In 1967 Arzewski moved to Boston, MA and studied at the New England Conservatory with Joseph Silverstein, who became her mentor.

[5][4] In 1987, Arzewski joined the Cleveland Orchestra as Associate Concertmaster, working with Music Director Christoph von Dohnányi.

[6][4][1] She served as the Atlanta Symphony Orchestra's concertmaster from 1990 to 2008, working with Music Directors Yoel Levi and Robert Spano.

[2] Over the course of her distinguished orchestral career, prior to arriving in Atlanta, Arzewski performed under the batons of William Steinberg, Eric Leinsdorf, Eugene Ormandy, Leonard Bernstein, Kurt Masur, Bernard Haitink, Claudio Abbado, Sir Colin Davis, Sir Simon Rattle, Christoph von Dohnanyi, Yoel Levi, Lorin Mazel, and James Levine.

Arzewski owned and played for the bulk of her career a violin by Pietro Guarnerius of Mantua, 1714, titled "Geza de Kresz, ex Caressa".

After stepping down from her position as the Atlanta Symphony Orchestra Concertmaster, Arzewski became the Artistic Director for the 2008 and 2009 North Georgia Music Festivals.

[10] This story features a dog named Gustav, found sick in the Chattahoochee National Forest.

[1][12] She made other Carnegie Hall concerto appearances for Bach Sonatas for Unaccompanied Violin and the Three Concertmasters Concert.

[13] Arzewski has performed in Boston, New York City, Cleveland, Atlanta, and Lieges Paris with artists such as Pinchas Zukerman, Emanuel Ax, Andrew Watts, Joseph Silverstein, Philippe Entremont, Iona Brown, and Lois Shapiro.

In 1978, Arzewski was an award winner at the Twentieth Bach International Competition at Merriweather Post Pavilion in Columbia, M.D.