Although particularly eminent in Verdi's works, she sang a wide repertoire during her 25-year career, including Rosaura in the world premiere of Mascagni's Le maschere.
She also appeared in Boston (in 1909–10), at the Teatro Solís, Montevideo (1911), at the Liceu, Barcelona (1911–12), at the Mariinsky Theatre, St Petersburg (1914)—and at numerous less important venues in her homeland and abroad.
In Italy in the 1900-1920 period, she was considered to be one of the finest interpreters of several Verdi heroines, including the title role in Aïda, Amelia in Un ballo in maschera, and Leonora in both Il trovatore and La forza del destino.
In an era of dynamic and passionate singing-actresses (such as Gemma Bellincioni, Eugenia Burzio and Rosina Storchio in Italy and Emmy Destinn in New York), Boninsegna's acting skills were dull in comparison, and her career suffered to some extent as a result.
Furthermore, with the exception of the part of Santuzza in Cavalleria rusticana and the title role in Puccini's Tosca, Boninsegna was either unfamiliar with, or simply not cast in, the verismo repertory which was highly popular during the time that she was performing—a problem that prejudiced her career.