Individuals with this syndrome present the following symptoms: carpal, metacarpal and digital synostoses, disorganization of carpal bones, numeric reduction of digital rays and toe syndactyly.

Additionally, other symptoms may include radioulnar synostosis, brachymesomelia, radius head dislocation, metatarsal synostoses and numeric reduction of rays.

[citation needed] Cenani–Lenz syndactylism is inherited in an autosomal recessive manner.

[citation needed] In a test of the theory that the locus associated with the disorder was at 15q13-q14, FMN1 and GREM1 were eliminated as candidates.

[6] The syndrome is named after Turkish (Asim Cenani) and German (Widukind Lenz) medical geneticists.