The campus is approximately 15 miles (24 km) east of Research Triangle Park and Raleigh-Durham International Airport, and 5 minutes from downtown Raleigh.
It also houses an automated book retrieval system, called the "BookBot," and the Institute for Emerging Issues (IEI), a public-policy organization.
The Keystone Centennial Science Center, a 72,000 sq ft (6,700 m2) lab and office space complex, as well as Engineering Building III, were completed during the summer of 2010.
In addition, the Graduate School and the College of Engineering's Golden LEAF Biomanufacturing Training and Education Center (BTEC) are located on the campus.
In order to lease space on the property, a prospective "partner" must have some programmatic connection to NC State, such as collaborative research with a faculty member or the use of students for internships or part-time work.
Currently, about one-third of the partners are start-up or early stage companies, many located in Centennial's co-working incubator, Raleigh Founded.
Current partners include, Hitachi Energy, U.S. Department of Agriculture, IBM, LexisNexis and the National Weather Service's regional office.
BTEC provides education and training in biomanufacturing and bioprocessing involving simulated cGMP production of high-value biomolecules using cell growth and expression, recovery and purification processes.
Finally, Centennial Campus is home to the Larry K. Monteith Engineering Research Center, which houses several clean rooms.