Conference members have won seventeen NCAA team titles: Johns Hopkins women's cross country (2012, 2013, 2014, 2016, 2017, 2019, 2021), Gettysburg women's lacrosse (2011, 2017, 2018), Haverford men's cross country (2010), Franklin & Marshall women's lacrosse (2007, 2009), Ursinus field hockey (2006), Washington men's lacrosse (1998), and Washington men's tennis (1994, 1997).

According to the Centennial Conference's website, "On June 4, 1981, Keith Spalding, then-president of Franklin & Marshall College, made the announcement that "eight private colleges found it timely and appropriate to form a round-robin football schedule among institutions with similar attitudes and practices in intercollegiate football competition."

Those three schools accepted and became charter members in 1992 as the conference expanded its sports offerings.

[3] All of the charter members defected from the Middle Atlantic Conference (MAC).

Johns Hopkins and McDaniel College both played in the Mason-Dixon Conference prior to entering the MAC in 1975.