48% of the students are Second-Language Learners (SLL) with 33% of the total enrollment classified as Limited English Proficiency (LEP).

The certificated staff and faculty at Centennial High School is ethnically composed of the following as of 2009:[3] The California Department of Education mandates a qualification for subject teaching known as a "Clear Credential".

[9][10][11] Centennial High School has not met its state-identified goals for student progress in all areas each year since 2006.

Students failed to meet the No Child Left Behind Act's Adequate Yearly Progress (AYP) requirements in English Language Arts (ELA) or Mathematics for all significant subgroups.

The Centennial Apaches compete in the Bay League of the California Interscholastic Federation (CIF).