Riskin's academic plunge into Jewish–Christian relations began in the early 1960s when he attended seminars, held by Professor David Flusser, about the Christian Gospels at The Hebrew University of Jerusalem.

[5][6] Since Riskin's retirement as president of Ohr Torah Stone institutions in 2018, the overseeing of all CJCUC activities has been turned over to David Nekrutman who has served as the center's chief director since its inception.

[2] CJCUC hosts Christian groups from all over the world for all-day seminars,[7][8][9] which include tours of biblical sites such as nearby Jerusalem, the Path of the Patriarchs and the Herodian wells.

Among the subjects that the seminar series includes are Jewish–Christian Relations; the Theology of Biblical Holidays; Covenant and Mission; The Ten Commandments; Satan, Evil and Free Will; Judaism and the Ministry of Jesus; and Human Life Created in the Image of God.

[16] In February 2015, on a visit to Oklahoma, Rabbi Riskin unveiled plans for historic high school curricula, being worked on in a joint effort with the government of Israel, detailing advancements in Jewish–Christian relations.

In October 2014, Riskin became the first Orthodox rabbi to invite Christian visitors to Israel to participate in a "praise rally" with Jewish interfaith leaders at the Center's headquarters during the holiday of Sukkot.

[36][37] In October 2013, CJCUC Executive Director, David Nekrutman published a controversial appeal for funds from Jews to support the purchase of a permanent site for the Christian-Arab church of Pastor Steven Khoury.

[38][39] In May 2014, CJCUC sponsored an interfaith Latin American clergy mission that visited the Ziv Medical Center in Safed, Israel, donating supplies to wounded Syrian civil war refugees.

[49][50][51][52][53][54] The unprecedented statement, entitled "To Do the Will of Our Father in Heaven: Toward a Partnership between Jews and Christians", was initially signed by over 25 prominent Orthodox rabbis in Israel, United States, and Europe.