Centertown is a home rule-class city in Ohio County, Kentucky, in the United States.

Incorporated in 1890, the city is named for its location between Hartford and the Green River shipping port of Point Pleasant.

According to the United States Census Bureau, the city has a total area of 0.3 square miles (0.78 km2), all land.

As of the census[5] of 2000, there were 416 people, 164 households, and 126 families residing in the city.

18.9% of all households were made up of individuals, and 11.6% had someone living alone who was 65 years of age or older.