Central Bethlehem Historic District is a national historic district located in Bethlehem in Lehigh and Northampton counties in the Lehigh Valley metropolitan area of eastern Pennsylvania.

It is primarily residential, but also includes commercial buildings along Main Street.

The buildings are primarily 2+1⁄2 stories tall and constructed of brick or stone.

The district encompasses buildings that reflect Bethlehem's development from a Moravian community between 1741 and 1844, to an industrial based economy from 1845 to the late 20th century.

Located in the district is the separately listed Lehigh Canal.