The central business district is Ward 6 of a Mayor-Council government represented by councillor Cynthia Block.

For clarification, the post offices adopted the titles Saskatoon down town and Nutana (meaning "first born") for the east side of the River settlement.

[4] Section 28, Twp.36, R.5, W3 was the location of West Saskatoon Post office located at 21st & 1st Ave.[5] With settlement on the west side of the river, 32 children needed to cross the river to attend the Stone School on the east side where there were 67 students in total.

1928 saw Eaton's opening in the building on 21 Street and Third Avenue, which later housed the Army and Navy Department Store and now the Saskatoon Board of Education offices.

The armouries of the 29th Saskatchewan Light Horse Regimental Headquarters and 105th Fusiliers Division were constructed in south downtown in 1922.

The Saskatoon downtown revitalization project began in the 1950s and 1960s when the Canadian National Railway yards were removed and replaced with a shopping mall in its image called the Midtown Plaza, and its neighbor the Saskatoon Centennial Auditorium and Convention Centre (recently renamed TCU Place).

The Hudson's Bay Company building on 23rd Street East and 2nd Avenue has been converted to condominium living, and the adjacent Bayside Centre is now owned by Ashley Furniture.

The 2nd Avenue Lofts is an example of one building originally intended for commercial operations that has in recent time been converted to residential.

[12] Second Avenue was revamped to provide angle parking and created a unique strip mall type of shopping area in the revitalised downtown core.

The ceremonies of July 30, 1970 celebrated the opening of Saskatoon's enclosed downtown shopping mall named Midtown Plaza and developed on the former CNR yards.

The Scotia Centre Mall houses office of the Potash Corporation of Saskatchewan and boutiques and restaurant.

Currently the central business district lies within the Saskatoon West riding and has been represented by Brad Redekopp of the Conservative Party of Canada since 2019.

[21] In Saskatoon's non-partisan municipal politics, the Central Business District lies within ward 6.

[24] There are health professional offices in the central business district, such as physician, dentist, optometric services.

The Arena was replaced by Saskatchewan Place, now known as Credit Union Centre, on the city's outskirts, while the construction of Centennial Auditorium (now TCU Place) and improvements to the Exhibition Grounds led to these venues becoming preferred for concerts and other specialty events in the later years of the arena's history.

Opened in 1964, the Mendel Art Gallery is located on Spadina Crescent East and overlooks the South Saskatchewan River near the base of the University Bridge.

The Art Placement Gallery is a commercial enterprise on 3rd Avenue South[29] The Saskatoon Centennial Auditorium was opened April 1, 1968.

The Roxy Theatre, for time called the Towne Cinema, is located nearby in the Riversdale neighbourhood.

[34] Saskatchewan Transportation Company operates a major bus depot in downtown Saskatoon on 23rd Street and Pacific Avenue or the Warehouse district.

Highway 14 connects with Asquith, Biggar Wilkie, Unity, and Macklin en route to Alberta.

Saskatoon is developing the South Central Business District, or block 146, which is called the River Landing Project.

Persephone Theatre is one of the first tenants on site, developing the Frank & Ellen Remai Arts Centre that opened in the winter of 2007.

[37][38][39] In December 2004, Premier Lorne Calvert, allocated $29.3 million to finance Saskatoon's River Landing project on the A. L. Cole Power Plant site.