CFRP is home to numerous centers hosted by the United States Department of Defense, UCF, and private corporations.

Planned to provide a campus-like environment for business and military modeling, simulation, and training (MS&T) commands and activities adjacent to UCF, the CFRP covers over 1,027-acre (4.16 km2), directly south of UCF's 1,415-acre (5.73 km2) main campus in Orlando.

Given the importance of simulation and training to the Department of Defense, an extensive military presence is also located in the park centered on the Orlando area's last remaining active duty military installation, Naval Support Activity Orlando.

Tenant commands at NSA Orlando include the Naval Air Warfare Center Training Systems Division (NAWCTSD), the U.S. Army Program Executive Office for Simulation, Training, and Instrumentation (PEO STRI), activities of the U.S. Army's Research, Development and Engineering Command United States Army Simulation and Training Technology Center (STTC), the Marine Corps Program Manager for Training Systems (PM TRASYS), and the Air Force Agency for Modeling and Simulation (AFAMS).

Over $1.4 billion in federal contracts is awarded by the U.S. military each year for activities in and in the vicinity of the park.