[5] The development ultimately led to $20 million (1905 $USD) worth of streets, sewers, rail facilities, docks, and other improvements.

[6] In 1911, the Wrigley Company built a 175,000 square foot factory at the corner of West 35th Street and South Ashland Avenue.

Fire safety was assured by spreading apart the buildings, by wire-glass windows and metal frames, and by the CMD's 250,000-gallon sprinkler tower.

According to Central Manufacturing District Magazine, lots were standardized "to accommodate the most economical building units, to eliminate waste ground, and to give an ideal arrangement of improvements and facilities with easy accessibility.

"[11] Concrete tunnels were dug between plants and the CMD's freight station so that electric tractors could haul goods back and forth.

In 1957, the Stockyards-Kenwood elevated railway shut down after twenty years of deferred maintenance, limiting commuter options into the C.M.D.

[13] After changing hands several times, the Wrigley Factory at West 35th Street and South Ashland Avenue was demolished.

[16] Chicago itself lay at the geographical nexus of the nation's productive activity, at the center of its markets and the hub of its railways.

It does not include the entire area of the Central Manufacturing District with its contributing properties limited to the ranges of 3500-3700 blocks of South Morgan Street.

[18] In 2017, there was community discussion of changing the area from one of commercial and industrial use by converting some of the buildings into multi-family and senior housing.