Central School Campus, also known as Central School and DeSoto High School, is a historic school complex located at De Soto, Jefferson County, Missouri.

The Central School was built about 1882, and remodeled into its current form in 1950.

The DeSoto High School was built in 1927, and is a three-story, textured brick building with a flat roof and accented with limestone or cast stone ornament reflecting the Classical Revival style.

[2]: 5 It was listed on the National Register of Historic Places in 2009.

This article about a property in Jefferson County, Missouri on the National Register of Historic Places is a stub.