Starting in 1906, Kentucky won the first three games but only before Centre College did the same, tying the series at 3.

The series was put on hold in 1910 and resumed in 1912 with Kentucky winning both games that year.

The next year the two met in Danville, with the result being the same, Kentucky blowing out Centre 38–5.

The Colonels would rally of six straight wins over the Wildcats, once again taking the series lead over Kentucky.

Kentucky would defeat Centre in every game after 1924, carrying their win streak to a total of 11 by the end of the series in 1930.