Centre Avenue is a main thoroughfare in Pittsburgh, Pennsylvania, United States.

It stretches from Sixth Avenue near the Allegheny County Courthouse to East Liberty.

At its other terminus, it was shortened by about 1000 feet (320 m) when East Liberty was re-designed and Penn Circle South produced.

Charts produced prior to 1970 were drawn with Centre Avenue longer than its current length.

Centre Avenue was extended in 2014, when the streets composing Penn Circle were renamed to their old names.