Centre Inn is an unincorporated rural community in Guelph/Eramosa Township, Wellington County, Ontario, Canada.

[3] Duffield owned 100 acres (40 ha) of land on the corner of Fourth Line and Eramosa Road, the location which became known as Centre Inn.

[5] A hotel was operated on the main corner of Centre Inn, and was used by people travelling by horse-drawn carriage between Erin and Guelph.

[6][7][8] In 1833, John Loree donated land to establish the Centre Inn Cemetery.

[5] George Caughlin had a 296-acre (120 ha) farm in Centre Inn with a race track.