[4] They are a type of protein that is essential and present in almost all eukaryotic cells and are found in the centrioles and pericentriolar lattice.

[6] Jeffrey Salisbury, who discovered centrin in the green algae, and his colleagues used RNA interference (RNAi) to reduce the levels of centrin-2 in human tissue culture cells.

[5] Centrins show calcium-sensitive contractile behavior and was identified before as a calcium sensing regulator of the centriole structure.

[9] It is one of the first proteins to localize at sites of newly forming centrioles in semiconservative and novo assembly pathways.

[11] The extra-centrosomal materials function is not yet fully understood by researchers yet but using cross linking found centrin does have an affinity for actin and the terminal portion of the HC.

[13] Centrins contain four helix-loop-helix features specifically made binding with calcium in the transitional region of the axoneme.