However, due to a row a teeth along the upper jaw,[3] it is unable to release prey from its mouth causing it to potentially die by choking.

[4] At extreme temperatures (both high and low), Cranwell's horned frog enters a period of estivation, developing a thick layer of protective skin to trap moisture and aid in respiration.

[citation needed] It is also a good practice to dust prey items with an appropriate calcium and multi-vitamin supplement to prevent the development of metabolic bone disease.

Because of its large mouth, C. cranwelli is particularly susceptible to impaction especially when young, a condition whereby the frog's gastrointestinal tract is obstructed by a foreign body accidentally swallowed.

Impaction often leads to constipation and malnutrition, and possibly death unless treated promptly with laxatives such as the osmotic diuretic lactulose.

In severe cases, the volume of feces in the intestines is so large that the lungs are obstructed and the frog's breathing is impaired.