Cesare Zerba (15 April 1892 – 11 July 1973) was an Italian cardinal of the Roman Catholic Church.

He served as Secretary of the Sacred Congregation for the Discipline of the Sacraments in the Roman Curia from 1958 to 1965, and was elevated to the cardinalate in 1965.

Cesare Zerba was born in Castelnuovo Scrivia, and studied at the seminaries in Stazzano and Tortona, the Pontifical Roman Athenaeum S. Apollinare in Rome, and the University of Pavia.

He received his episcopal consecration on the following 21 September from Pope John himself, with Archbishops Francesco Carpino and Pietro Parente serving as co-consecrators, in the Lateran Basilica.

Pope Paul VI created him Cardinal Priest of Nostra Signora del Sacro Cuore in the consistory of 22 February 1965.