[15] The last of Pietro's sons, Angelo or Agnolo, married Franceschina Cardoli, a descendant on his mother's side of the famous condottiero Gattamelata; he himself was a very distinguished personage of his time, becoming a jurisconsult, professor of the Roman Archiginnassio, consistorial lawyer and senator like his father until he was noticed by Pope Julius II, who appointed him first apostolic secretary and then auditor of the apostolic chamber.

[15] He was also a splendid patron, commissioning Michelangelo to build the family chapel in the church of Santa Maria della Pace in Rome.

Giangiacomo's son, Angelo, followed in his father's footsteps and was also a decemvir at Todi and a nobleman at Terni, embarking like his parent on a military career on behalf of the Church State.

[15] In 1569, during the reign of Pius V, he commanded a military expeditionary force in France to bring aid to Charles IX against the Huguenots.

[15] He had a palace in Rome in via della Maschera d'oro that later became the seat of his household and erected a grand mausoleum to his uncle, Cardinal Federico Cesi, in the church of Santa Maria Maggiore.

[15] His sons were Bartolomeo, who later became archbishop of Conza, bishop of Tivoli and cardinal, and Federico, who first assumed the title of marquis of Monticelli.

At this point the branch of the dukes of Acquasparta was succeeded by the one originated by Bartolomeo with Giacomo di Giuseppe who in 1804 and then with his son, Luigi in 1821.