Cadillac-sur-Garonne (French pronunciation: [kadijak syʁ ɡaʁɔn], literally Cadillac on Garonne; Gascon: Cadilhac, known as Cadillac until 31 December 2022[3]) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.

Cadillac-sur-Garonne was founded in 1280 to serve as a river port for the castle of Benauges by the lord of the castle, Jean I de Grailly.

Cadillac-sur-Garonne is directly across the Garonne river from Sauternes, and is known for producing sweet dessert wines under the Cadillac AOC designation.

Cadillac-sur-Garonne is the home of the imposing Château des Ducs d'Épernon.

The name of the town was adopted by Antoine Laumet de La Mothe, sieur de Cadillac, the founder of Detroit and Governor of Louisiana, on his arrival to what is now the United States.