Châteauneuf-de-Gadagne (French: [ʃɑtonœf də ɡadaɲ]; Occitan: Gadanha) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in Southeastern France.

The Félibrige was founded in Châteauneuf-de-Gadagne, at Font-Ségugne, in 1854.

Châteauneuf-de-Gadagne is located 12 km (7.4 mi) east of Avignon.

It is served by Gadagne station (opened in 1868) on the line from Avignon to Miramas.

Châteauneuf-de-Gadagne is twinned with: