The Chūgoku Expressway (中国自動車道, Chūgoku Jidōsha-dō) (part of Asian Highway Network AH1) is an expressway in Japan, which extends from Suita, Osaka to Shimonoseki, Yamaguchi.

It connects Kansai and Chūgoku regions in western Honshu, Japan's main island.

Other major cities along the expressway are Tsuyama, Kobe, and Hiroshima.

It was opened in 1970, and has a total length of 540.1 kilometers (335.6 mi).

On 5 October 2013, comedian and singer Yakkun Sakurazuka died in an accident on the Chugoku Expressway in Mine, Yamaguchi, while en route to a concert in Kumamoto Prefecture.