Chain-O-Lakes is a village in Roaring River Township of southeast Barry County, Missouri, United States.

According to the United States Census Bureau, the village has a total area of 0.08 square miles (0.21 km2), all land.

29.8% of all households were made up of individuals, and 17.6% had someone living alone who was 65 years of age or older.

The racial makeup of the village was 96.06% White, 0.79% Native American, and 3.15% from two or more races.

There were 3.2% of families and 7.8% of the population living below the poverty line, including 21.4% of under eighteens and none of those over 64.