The eparchy extends its jurisdiction over the faithful of the Chaldean Catholic Church of Syria.

It is directly subject to the Chaldean Catholic Patriarch of Babylon (actually in Baghdad, Iraq), not part of any ecclesiastical province.

A colony of Chaldean Christians was certainly present in Aleppo in the early 16th century, most probably from the city of Diyarbakır in Upper Mesopotamia.

However, the number of the Chaldean faithful remained always reduced; at the beginning of the twentieth century the community included only 250 people.

The eparchy was erected on July 3, 1957, with the bull Almost pastor[2] of Pope Pius XII, with which the pontiff suppressed the Chaldean Catholic Eparchy of Gazireh of the Chaldeans and established the new ecclesiastical circumscription.