Cham Khalaf-e Isa Rural District (Persian: دهستان چم خلف عیسی) is in Cham Khalaf-e Isa District of Hendijan County, Khuzestan province, Iran.

[4][a] At the time of the 2006 National Census, the rural district's population was 2,701 in 515 households.

[7] The 2016 census measured the population of the rural district as 2,524 in 695 households.

The most populous of its 16 villages was Karimabad, with 566 people.

This Hendijan County location article is a stub.