Anthony Draco (Danova) and Harold Blount (Hyde-White) are proprietors of a wax museum in Baltimore who are also amateur sleuths.

Using the missing judge as a reference, Draco asks Marie to pose for him in order to make a wax model of her.

Draco and Blount conclude that the mysterious murderer is delivering a corpse of a man to the police piece-by-piece, with the arms and head still missing.

When Draco accidentally surprises Marie with a wax dummy of the dead judge, she realizes her role in the murders and tells them the story of the man with the severed hand she met in New Orleans.

Now realizing that they are up against a man they thought dead, and that he is no doubt seeking to kill the rest of his enemies as a way of finishing the "body", Draco, Blount, and the police set up a dragnet for the escaped murderer.

Remaining inside his museum all night with Marie and Blount, and with the police protecting the building, Draco awaits the arrival of his deadly nemesis.

Chamber of Horrors was released on DVD by Warner Home Video in September 2008 with a co-feature, The Brides of Fu Manchu.