Chambon-Sainte-Croix (French pronunciation: [ʃɑ̃bɔ̃ sɛ̃t kʁwa]; Occitan: Chambon Senta Crotz) is a commune in the Creuse department in the Nouvelle-Aquitaine region in central France.

A small farming and forestry village situated some 15 miles (24 km) northwest of Guéret, at the junction of the D22, D46 and the D951 roads.

The Petite Creuse river forms the northern and eastern borders of the commune.

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