[2]: 22–24, 29 According to the Chilam Balam of Chumayel, the Itzáes began to arrive at the Yucatán peninsula in the year 435, begun in Bacalar and rising to the north and west, in this way they also inhabited Chakán Putum.

After the Yucatán Peninsula, was divided into 16 cacicazgos, in the state of Campeche, was part of the chiefdom of Ah Canul, Can Pech, and Chakán Putum.

According to the story of the soldier and chronicler Bernal Díaz del Castillo, it is known that three days later the expeditionaries continued along the coast and reached Chakanputún, which they renamed Champoton and where they met with a thousand heavily armed Maya who attacked the Spaniards by killing to more than 50 and leaving the captain wounded.

After this fierce fight, the Spaniards had to flee without water and with many wounded, 57 dead and two kidnappings (Alonso Boto and an old Portuguese), the same Hernández de Córdoba left with 33 wounds, because the Mayans soon realized that he was the boss and as described by Diaz del Castillo shouted "calachuni", "calachuni" (which means "the boss"), they fled to Florida, a place known by the pilot Antón de Alaminos looking for water, but there they were also repelled by the natives (Bernal Díaz del Castillo who participated in the trip, was wounded in Florida) and finally returned to the port of Carenas near Havana in Cuba, Hernández de Córdoba would die 10 days later as a result of injuries in Sancti Espiritus.

After a strong confrontation ( Battle of Centla ), Cortes subdued and agreed with the Mayans founding the town of Santa Maria de la Victoria, (Frontier).

Alonso Dávila was sent by Montejo to cross the peninsula south and founded in Bacalar Villa Real, but this position had to be abandoned.

In 1543 the crown appointed Fray Bartolomé de las Casas to be bishop of Chiapas, its jurisdictional limits included Champotón.

During the Viceroyalty the city, head of an important sugar producing region, had a population composed of Spaniards, Mayans and black slaves, and was attacked in 1644, 1672 and 1748 by English pirates, which caused considerable damage.

By decree of Governor Miguel Barbachano of May 1, 1852, Champoton is elevated to the category of village and when the district of Campeche becomes a state, it becomes part of the new entity.

On November 19, 1863, there was a landing in Champotón by French forces who made a sudden and surprising attack, taking possession of the San Antonio Fort.

Dr. Alberto Trueba Urbina made the formal declaration at the premises of the choreographic society "Cultura y Progreso" (current village casino) on December 8 of the same year at 11:30 am; he was municipal president the prof. Abraham Aguilar Espinosa.