Chance Thomas Leo Sisco (born February 24, 1995) is an American professional baseball catcher in the St. Louis Cardinals organization.

He has previously played in Major League Baseball (MLB) for the Baltimore Orioles and New York Mets.

Sisco initially attended Temescal Canyon High School in Lake Elsinore, California.

[6] Sisco made his professional debut that season for the Gulf Coast Orioles and ended the year with the Aberdeen IronBirds.

[2] He won the SAL batting title after hitting .340 with five home runs, 63 RBIs and a .854 on-base plus slugging (OPS).

[9] In 2015, Sisco played for the Frederick Keys and the Bowie Baysox where he batted a combined .297 with six home runs and 34 RBIs in 95 games.

[16] He made his MLB debut the following night as a defensive replacement in the ninth inning of a 7–2 loss to the Toronto Blue Jays at Camden Yards.

In 59 games for the Orioles in 2019, Sisco posted a batting line of .210/.333/.395 with career-highs in home runs (8) and RBI (20).

[20] Sisco began the 2021 season sharing catching duties with Pedro Severino, but was optioned to Triple-A Norfolk in favor of Austin Wynns on May 31 after stumbling to a .154/.247/.185 batting line in 23 games.

[25] On March 16, 2022, Sisco signed a minor league deal with the Seattle Mariners that included an invite to spring training.