A leading figure of the Mandopop music scene since the mid-1990s, A-Mei is widely known for breaking ground for Taiwanese indigenous peoples and being a voice for LGBT rights and gender equality.

[9] In 2017, she was included in the "Charity Heroes List" by the Asian edition of Forbes, and her influence is even greater than that of many famous Taiwanese political and business figures.

[24] After her father's death, A-Mei struggled to recall her passion for music until 1995 when she began to sing in local pubs with a rock band called "Relax" which was formed by her musician cousin.

[25] After she signed a recording deal with Forward Music she made an appearance on Chang Yu-sheng's album, Red Passion, which was released on 12 July 1996, where they sang a duet titled "The One Who Loved Me Most, Hurt Me The Most (最愛的人傷我最深).

"[26] In November 1996, when A-Mei was invited to sing "I'm a Dreamer on Air (空中的夢想家)," the theme song for Taiwan's UFO Radio station, she again drew attention from the public.

[36] The songs on Sisters such as "You Don't Want Anything (原來你什麼都不要)," "Released (解脫)," "Cut Love (剪愛)" and the titular track enjoyed hefty radio airplay throughout the Sinophone world.

On the album's titular track, Chang invited A-Mei's mother, sisters and other relatives to participate in the chorus singing and added Puyuma musical elements to make the song more culturally enriching.

[43] The album Bad Boy spawned numerous hit singles such as the title track, "Can't Cry (哭不出來)," "Whenever I Think About You (一想到你呀)," "Dancing Alone (一個人跳舞)" and "Listen to the Sea (聽海)."

[50] However, tragedy struck five months after the album's release; her manager Chang died on 12 November 1997, at age 31, after falling into a coma for 24 days due to a car crash that occurred on 20 October 1997.

[25] Due to her immense fame, A-Mei was formally invited by the Japanese public broadcaster NHK to perform as a representative of Taiwan in the annual ceremony "Asia Live Dream" in February 1998.

In the album, A-Mei sang the posthumous works "Are You Ready" and "Her Consciousness (後知後覺)" of her mentor Chang Yu-sheng and for the first time collaborated with Taiwanese singer-songwriter David Tao, who had just risen in the music scene.

She became the first Taiwanese singer to perform at the Shanghai Stadium, with the seats at the venue filled to the brim; it is notable that there were nearly 80,000 attendees attending the show, making it the most successful concert in that city's history.

[75] At the Taipei Municipal Stadium, she became the only female singer to "open the entire venue" to a crowd of nearly 50,000 people, thus being regarded as a major benchmark in Taiwan's concert history.

[9] On February 4, 2000, she was invited to CCTV Spring Festival Gala 2000, where she sung the song "Give Me Feelings (给我感觉)," which is a treatment that many famous singers have never had the chance to enjoy.

[92] CNN called A-Mei the "Asian Music Ambassador" and praised her for taking the mainland by storm with her singing at a time when cross-strait relations were tense and everchanging.

[95] Under pressure from Beijing, Sprite also buckled and cut its contract with A-Mei by removing her as its endorser, meanwhile contemporary hit radio stations in China temporarily ceased broadcasting her music.

[104] After finding a home in June 2001 with Warner Music Taiwan, A-Mei sang the Mandarin theme song for the movie Pearl Harbor, which was a cover of Faith Hill's "There You'll Be.

"[105] In August, Beijing hosted the 2001 Summer Universiade; when she was invited to be a guest at the opening ceremony and sang the two songs "Sisters (姊妹)" and "Holding Hands (牵手)" at the finale, the entire venue of 80,000 people screamed and cheered.

[129] The commercial success of Brave convinced the record company to spend tens of millions holding three "It's Me Who's Missing You" summer concerts in Taitung's Seaside Park, Sizihwan and Fulong Beach.

[133] On 12 June 2004, A-Mei became the focus of international controversy when she was forced to abruptly cancel a concert in Hangzhou after students from Zhejiang University branded her a "supporter of Taiwanese independence.

"[135] Political issues aside, A-Mei gave a benefit concert in Taipei on 22 July 2004, for the victims of Typhoon Mindulle, which caused widespread destruction that summer, especially in the aboriginal areas in the country.

[158] Her live singing skills and stage charm were unanimously praised by the public, and the performance was regarded as her first big step to return to the pinnacle of the music scene after a brief slump.

[162] The album sales champion eventually sold over two million copies in Asia[163] and earned her a Golden Melody Award nomination for Best Female Mandarin Singer.

[168][169] In April 2007, EMI Taiwan spent more than ten million to hold a pan-Asian press conference in Hong Kong that was meant to announce the signing of A-Mei to their company.

[188] On 5 September 2009, she became the spokesperson for the 2009 Summer Deaflympics held in Taipei and participated in the opening ceremony as a guest, singing the theme song "Dreams You Can Hear (聽得見的夢想).

[199] In June 2011, A-Mei ranked first in a Forbes survey of "The 25 Most Famous Taiwanese in Mainland China," making her influence bigger than that of many well-known political and business figures.

[203] During the tour's London stop on, she became the first Chinese-speaking female singer to hold a large-scale solo concert at The O2 Arena in England, setting a precedent for Taiwanese popstars in the European music market.

[216] All in all, the tour played a total of 55 shows in Taiwan, Mainland China, Hong Kong, Macau, Singapore, Malaysia, Japan, Thailand, New Zealand, Australia, Canada and the United States.

[220] On 16 May 2018, her album Story Thief earned six nominations at the 29th Golden Melody Awards and won Best Music Video for "Left Behind (身後)," which was directed by Lo Ging-zim.

[223] On 6 September 2018, A-Mei was invited to sing her latest single "If Only" with one of the world's leading tenors, Andrea Bocelli, at the Celebrity Fight Night charity gala in Italy in 3 languages: Italian, English and Chinese.