Changji Hui Autonomous Prefecture (Chinese: 昌吉回族自治州; Uyghur: سانجى خۇيزۇ ئاپتونوم ئوبلاستى) is an autonomous prefecture for Hui people in the middle north of Xinjiang Uyghur Autonomous Region, Western China.

The prefecture has an area of 77,129 km2 (29,780 sq mi) and its seat is Changji City.

Changji directly controls 2 county-level cities, 4 counties and 1 autonomous county.

According to the 2010 census, Changji had a population of 1,428,587 inhabitants, with a population density of 19.4 inhabitants per km2.

Part of the change in population is due to boundary changes, for example, the formerly county-level city Miquan was merged into Midong District and became part of Ürümqi in 2007.