As a junior in 1999–2000, he averaged 15 points, 12 rebounds, nine blocks and six assists per game for coach David Lopez as he led the team to a 26–7 record, a berth in the Class 5A state tournament semi-finals and a No.

[2] As a senior in 2000–01, Frye averaged 22 points, 15 rebounds, six blocks and three assists per game and he led St. Mary's to the 2001 Class 5A state championship with a 30–3 record.

[2] Frye finished his four-year career at Arizona with eight double-doubles in 12 NCAA Tournament appearances while registering 93 double-figure-point and 35 double-figure-rebound games.

On February 3, in a game against the Orlando Magic, Thomas took Frye out of the starting lineup and replaced him with little-used center, Jerome James.

Thomas explained the change, saying, "I think Jerome is one of the best defensive big men in the game in terms of the center position.

"[5] Frye was selected to the 2005–06 NBA All-Rookie first team, and finished fifth in points (45) behind Chris Paul (58), Charlie Villanueva (56), Andrew Bogut (55), and Deron Williams (46).

On June 28, 2007, Frye was traded, along with Steve Francis, to the Portland Trail Blazers in exchange for Zach Randolph, Fred Jones and Dan Dickau.

[8] In February 2010, Frye was selected to the NBA All-Star Weekend Three-Point Shootout, becoming the first center invited since Sam Perkins in 1997.

[11] As a result, Frye filled in as a broadcaster during pre-game shows for the Suns, starting with the November 2 home game against the Detroit Pistons.

To recover from his heart defect, he took up yoga and golf, later on enduring more basketball related challenges like running and mid-range shooting.

[16] Acquired for his ability to stretch the floor and for his outside shooting, Frye, in just his second game as a Cavalier on February 24, hit four three-pointers and finished with 15 points off the bench in a 114–103 win over the Charlotte Hornets.

[17] In the Cavaliers' 2016 second round playoff series against the Atlanta Hawks, Frye helped the team go up 3–0 with 27 points on 10-of-13 shooting, including 7-of-9 from three-point range, in a Game 3 win.

[20] Frye helped the Cavaliers go 12–1 over the first three rounds of the 2017 playoffs to once again reach the NBA Finals, where they lost in five games to the Golden State.

Channing Frye is also a proud supporter of the Purple Penguins of the AFF league, where his brother-in-law Sam Nelson is on the team.

[33] In 2020, he launched Chosen Family Wines and then partnered with Kevin Love, his former teammate and a close friend, along with Jacob Gray, and Chase Renton.