Nevelson designed the five-sided sanctuary space by incorporating various abstract sculptural elements such as reliefs, columns, and an altarpiece made with materials that included found objects from New York City streets.

The installation has been compared to other 20th-century spiritual spaces designed by prominent artists, including Chapelle du Rosaire de Vence by Henri Matisse, emphasizing the transformative potential of modern architecture.

[5] Louise Nevelson, an American sculptor, gained prominence for her abstract and dark monochromatic three-dimensional installations usually made with wood or metal.

[8] When she was asked about her role in creating a Christian sanctuary space as a Jewish artist, Nevelson responded that the abstract quality of her work "transcended" traditional denominational barriers.

[10] Art historian Marchita Mauck described the Nevelson Chapel as a "healing place" where the "stark simplicity" of its environment "conveys strength, presence, [and] peace".