[5] On 25 January 2012, he made his debut with the first team in a Greek Football Cup match against Panionios as a substitute in the 82nd minute in front of 15,000 fans.

[6] On 25 October 2012, Lykogiannis made his European debut in an away UEFA Champions League game against Montpellier HSC as a substitute in the 88th minute.

[7] Four days after his debut in UEFA Champions League, on 29 October 2012, Lykogiannis made his first appearance in an away game for Superleague Greece against Aris as a substitute in the 68th minute.

[13][14] On 6 August 2015, he made his debut with the club as a substitute in an away 1–1 draw against Rubin Kazan for the 2nd leg of the 3rd qualifying UEFA Europa League round.

[17] On 12 March 2017, Lykogiannis scored with a long distance kick after an assist from Barış Atik giving a lead of two goals in his club in a final 2–1 home win against Rapid Wien.

[20] On 25 November 2017, he scored the only goal with a wonderful kick after a corner from his teammate Peter Žulj, in the extra time of the game sealing a 1–0 home win against LASK Linz.

Lykogiannis scored his first and winning goal in the 108th minute (1–2 after extra time)[29] for Greece U19 in the semifinals against England U19 for the 2012 UEFA European Under-19 Football Championship finals that took place in Estonia.

On 24 May 2017, Lykogiannis received his debut call from Michael Skibbe to play for Greece in the match against Bosnia at the preliminary round of the 2018 World Cup.