Chariton County Jail and Sheriff's Residence is a historic combined sheriffs residence and jail located in Keytesville, Chariton County, Missouri.

It was built in 1906–1907, and is a 2 1/2-story, red brick building with Queen Anne-style detailing.

It has a high hipped roof with lower cross gables.

[1] The Chariton County Jail and Sheriff's Residence was demolished in 2019 due to structural instability.

This article about a property in Chariton County, Missouri on the National Register of Historic Places is a stub.