Like his younger brother and fellow architect Edward Middleton Barry, Charles Jr. designed numerous buildings in London.

Charles Jr. worked extensively on projects in London and East Anglia with fellow architect Robert Richardson Banks (1812–72), working from an office in Sackville Street,[1] and then collaborated with his shorter-lived brother Edward on several schemes.

His pupils included Sir Aston Webb (himself a later President of the RIBA and winner of the Royal Gold Medal).

His son was Lt Col Arthur John Barry CBE, TD, MICE (b.

A. J. Barry collaborated on major international engineering projects with his uncle, Charles Jr.'s brother John Wolfe-Barry, and Bradford Leslie and was the author of "Railway Expansion in China and the Influence of Foreign Powers in its Development" [London, 1910].