Charles Demôle (March 22, 1828 – June 18, 1908) was a French politician of the French Third Republic.
He was minister of public works (April 16, 1885 – January 6, 1886) in the government of Henri Brisson.
He was minister of justice (January 7–December 10, 1886) in the government of Charles de Freycinet.
He was a member of the Senate of France from January 5, 1879, until his death.
He served twice as vice-president of the French Senate (1891–1895, 1898–1902).