Charles Ernest Chamberlain (July 22, 1917 – November 25, 2002) was a politician from the U.S. state of Michigan.

He worked as a lawyer in private practice and as an Internal Revenue Service agent in the United States Treasury Department, 1946–1947.

In 1956, Chamberlain defeated incumbent Democrat Donald Hayworth to be elected as a Republican from Michigan's 6th congressional district to the Eighty-fifth Congress.

He only narrowly defeated Democrat Milton Robert Carr by 97,666 votes (50.68%) to 95,029 (49.32%) in what was otherwise a strong Republican year in 1972.

He had been a member of the American Legion, the Society of the Cincinnati, Veterans of Foreign Wars, and Kiwanis.