Charles F. Grainger (January 23, 1854 – April 13, 1923) was mayor of Louisville, Kentucky from 1901 to 1905.

During his term as mayor, the Jefferson County Armory was built, as was a new jail building and the main branch of the Louisville Free Public Library.

After his term as mayor he became president of the Louisville Water Company.

He is credited with helping build the prominence of the Kentucky Derby, increasing the purse from five to fifty thousand dollars during his term.

He died on April 13, 1923, of heart disease, and was buried in Cave Hill Cemetery.