At the same time, he inherited jointly with his older brother Henry Wenceslaus, the Moravian estates Šternberk and Jevišovice.

In 1619 Karl Friedrich was at the head of an embassy that had been sent to Prague by the Silesian Princes and Estates to invite the newly elected King of Bohemia Frederick V to an inaugural visit to Wrocław.

[2] In defense of the freedom of religion and the desire for political interference, Karl Friedrich and the Dukes John Christian of Brieg and George Rudolf of Liegnitz and the City Council of Wrocław founded on 9 August 1633 a league (German: Konjunktion) which stood under the protection of Saxony, Brandenburg and Sweden.

Karl Friedrich was the last male descendant from the Münsterberg line of the Poděbrady family in Oels.

Through the marriage of his only daughter, Elisabeth Maria with Silvius Nimrod, Oels and the Bohemian estate of Šternberk came in the possession of the House of Württemberg.