[12][13][14][15] During Tuttle's investigation into Tammany Hall's connection to organized crime and corruption, he discovered that Vause was paid $190,000 in return for obtaining pier leases for a shipping company.

[16] In another Tuttle case, Judge Albert Vitale was accused of owing $19,600 to gangster Arnold Rothstein, and was investigated by the Appellate Division of the Supreme Court for failing to explain how he accrued $165,000 over four years while receiving a total judicial salary of $48,000 during that same period.

[17] Vitale was removed from the bench and George Ewald, who succeeded him, was accused of paying Tammany Hall $10,000 in order to obtain the seat.

[24][25][26] Tuttle also successfully prosecuted the Moscahlades and Dachis Brothers arson rings, organizations responsible for several for profit fires in New York City.

[34][35][36] In 1930 Tuttle sent Albany's Democratic political boss Daniel P. O'Connell to jail in New York City for contempt of court.

He hoped to campaign on an anticorruption platform, but his opposition to federal prohibition drew fierce criticism from rural Drys.

During the campaign, Democrats mocked the Republican ticket of Tuttle (an alleged Wet) and lieutenant governor nominee Caleb Baumes (a prominent Dry who supported the Eighteenth Amendment) as asking for votes by trying to please all sides on the Prohibition issue.

Roosevelt's victory was attributed to Tuttle's position on Prohibition, as well as the hard economic times of the Great Depression, for which voters blamed Republicans.

[55][56][57][58] After losing the race for governor, Tuttle returned to practicing law as senior partner in the firm of Breed, Abbott & Morgan.