Charles Belknap Henderson (June 8, 1873 – November 8, 1954) was an American attorney, businessman, and politician who served as United States Senator from Nevada.

He served as first lieutenant in Theodore Roosevelt’s Rough Riders during the Spanish–American War, and was district attorney of Elko County from 1901 to 1905.

Henderson was appointed to the U.S. Senate on January 12, 1918, by Governor Emmet D. Boyle to fill the vacancy caused by the death of Francis G. Newlands.

[1] In 1934, Henderson was appointed a member of the board of directors of the Reconstruction Finance Corporation; elected chairman in 1941, he served until he resigned in 1947.

In 1953, a largely industrial town south of Las Vegas incorporated itself as Henderson, Nevada, naming itself after the former senator.