[1] Charles was 17 when Charlotte of Cyprus, titular Queen of Armenia and Jerusalem, surrendered her rights to Cyprus, Armenia, and Jerusalem to him.

[2] He was the next legitimate heir in line from King Janus of Cyprus and Armenia.

The kingdom itself was held by the Republic of Venice, but the Savoy dynasty continued to claim it.

Charles married his second cousin Blanche Palaiologina (Bianca di Monferrato) (1472–1519), daughter of William VIII, Marquess of Montferrat, and Elisabetta Sforza.

[3] After Charles died from tuberculosis, Blanche was regent of the Duchy of Savoy from 1490 to 1496.