He was educated at Rugby School and Trinity College, Cambridge, where he was bracketed senior classic with Lord Lyttelton in 1838.
It was in this capacity that he was celebrant for the marriage of the new Headmaster of Harrow School, the Revd Henry Montagu Butler, in December 1861.
[4] Vaughan was a well-known Broad Churchman, an eloquent preacher and an able writer on theological subjects, his numerous works including lectures, commentaries and sermons.
Vaughan wrote the first published New Testament commentary that utilized the scholarship of Brooke Foss Westcott and Fenton Hort.
In his 1859 book St. Paul's Epistle to the Romans: with notes Vaughan thanked Westcott for allowing him to use the text being prepared for the new recension.
Speculation ended when Phyllis Grosskurth discovered the diaries of John Addington Symonds, who attended Harrow School while Vaughan was headmaster.
Through this incident Vaughan was, in the words of Gathorne-Hardy, "... not for the first time... in the grip of a devastating physical passion which he was completely unable to control."
It read: "I have resolved after much deliberation, to take that opportunity of relieving myself from the long pressure of these heavy duties and anxious responsibilities which are inseparable from such an office, even under the most favourable circumstances."
According to Noel Annan, "only after the elder Symonds' death did Vaughan dare to accept the deanery of Llandaff, where his ordinands were known as 'Vaughan's doves.