He was born in Boston, Massachusetts, and attended The Roxbury Latin School and later Phillips Academy in Andover.

[2] Lowell was elected a member of the American Antiquarian Society in 1814,[3] and served on its board of councilors from 1820 to 1853.

[4] He married Harriet, daughter of Robert T. Spence, of Portsmouth, New Hampshire, an officer in the U. S. Navy.

After passage of the Fugitive Slave Law in 1850, he was asked to speak at a protest rally with other abolitionists including Frederick Douglas.

At the standing-room only Faneuil Hall rally to Repudiate the Fugitive Slave Law, on October 14, 1850, Reverend Lowell spoke first, and began the evening with a prayer: "May nothing be said and done here that shall not approve itself to Thee, the pure and holy God.

May the time shortly come, when this whole nation shall feel the injustice of making merchandise of human beings, and we shall act in consistency with, our profession as freemen and Christians.

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