Charles Kwame Takyi (born 12 November 1984) is a Ghanaian former professional footballer who played as a midfielder.

[2] He started playing for Tennis Borussia Berlin and joined the FC Schalke 04 youth setup when he was 15 years old.

He made his Bundesliga debut on 10 December 2005 against Hertha BSC Berlin, coming in as a substitute for Guy Demel in the 71st minute.

[7] He made his Superliga debut on 3 March 2013 against Nordsjælland, receiving a yellow card in the 38th minute of a 1–0 defeat.

The Ghana Football Association applied to FIFA for a nationality switch of Takyi in November 2011.